Randomized Trial of Fresh Frozen Plasma Versus Albumin in Acute Burn Resuscitation

Abstract

Severe burn injury results in an inflammatory response requiring proper fluid resuscitation due to increased capillary permeability. Colloid (fresh frozen plasma [FFP] and albumin) infusion during resuscitation appears to be beneficial, however the optimal dose, duration, and timing of these fluids are unknown. Our overall goal is to determine the efficacy, safety, and microvascular effect of colloids in critically injured burn patients. We hypothesize that FFP administration in burn resuscitation is as safe as albumin and is more efficacious in both reducing the total fluid volume required and correcting burn endotheliopathy.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1190442

Entities

People

  • Arek Wiktor
  • Blaire Balstad
  • Jaimielyn Burke

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood
  • Burns
  • Cardiovascular Physiological Phenomena
  • Cellular Structures
  • Colorado
  • Contracts
  • Data Analysis
  • Health Services
  • Infrastructure
  • Maryland
  • Materials
  • Medical Personnel
  • Professional Development
  • Standards
  • Students
  • Technology Transfer
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Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.