Tumor Metabolism as the Achilles Heel in Prostate Cancer

Abstract

The hypothesis of this proposal was that the inhibition of monocarboxylate transporters (MCTs) can overcome resistance to enzalutamide in therapy-resistant prostate cancer cells. In advanced prostate cancer, glycolysis produces high levels of the toxic by-product lactate. Hence, prostate cancer cells upregulate the expression of MCTs to aid in lactate export. High levels of expression of MCTs have been associated with poor prognosis and biochemical failure in prostate cancer. Our findings so far show that the inhibition of MCT activity can suppress survival and proliferation of enzalutamide-resistant cells preferentially and can inhibit the growth of enzalutamide resistant xenografts. In addition, we found that the combination of MCT inhibitors with enzalutamide reduced basal and compensatory glycolysis as well as extracellular acidification rates in enzalutamide-resistant prostate cancer cells. Once completed, our project may have an enormous impact on the future of prostate cancer research.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1190449

Entities

People

  • Nagalakshmi Nadiminty

Organizations

  • University of Toledo

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Aromatic Amino Acids
  • Biomedical Research
  • Branched-Chain Amino Acids
  • Buffers (Chemistry)
  • Capillary Electrophoresis
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Electrospray Ionization
  • Essential Amino Acids
  • Factor Analysis
  • Health Services
  • Inhibition
  • Mass Spectrometry
  • Medical Personnel
  • Metabolism
  • Metabolomics
  • Spectrometry
  • Statistical Analysis
  • Students

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Oncology
  • Prostate Cancer Biology.