Optimizing Surgical Debridement Following High-Energy, Open Trauma with Dynamic, Contrast-Enhanced Fluorescence Imaging
Abstract
The proposed study will enroll 180 patients with open fractures to determine whether bone perfusion parameters, as measured by indocyanine green (ICG)-based Dynamic Contrast Enhanced Fluorescence Imaging (DCE-FI), is a predictor of unplanned all-cause reoperation as defined by the Centers for Disease Control and Preventions (CDC) National Healthcare Safety Network reporting criteria. We will also modify and optimize the existing DCE-FI system for bone perfusion imaging in austere environments and/or forward operating units. This study represents the next important step towards optimizing surgical management of high-energy traumatic injuries, particularly in medical units supporting soldiers in battle. This will transform the current paradigm by providing military trauma surgeons with accessible tools that can be used by surgeons at any level of experience to objectively inform surgical debridement. In turn, this technique will directly improve patient outcomes after traumatic injury by reducing infection and complications requiring unplanned reoperation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190455
Entities
People
- Devin Mullin
- Ida L. Gitajn
- Jonathan T. Elliott
- Shudong Jiang
Organizations
- Dartmouth–Hitchcock Medical Center
- R Adams Cowley Shock Trauma Center
- University of California, Irvine