Use of Tranexamic Acid to Reduce Tissue Edema and Prevent Burn Wound Conversion
Abstract
The purpose of the experiments performed during the first year was to elucidate the effect of tranexamic acid (TXA) on burn wound conversion in a rat burn wound conversion model. The comb burn injury model is well validated in the literature for this purpose - particularly at 7-days post injury which represents the gold standard for this experiment. Our studies clearly demonstrated that burn wound conversion was reduced by treatment of rats within traperitoneal (IP) TXA at this time point. Furthermore, TXA demonstrated efficacy at 24, 48 and 72 hours after comb burn injury. Additionally, we were able to demonstrate that mitochondrial DNA - an established marker of tissue damage - was reduced at 24 and 48 hours. This finding indicates that TXA has significant cell protecting activity. These findings clearly demonstrate that tranexamic acid reduces burn wound conversion and has cell protective properties in the rat burn wound conversion model when compared to no treatment. In the second year of the project we completed experiment two - a comb burn model in the setting of a 30 percent TBSA burn injury. Similarly, we confirmed that the beneficial effects on burn wound conversion persist even in the more severe burn injury model (see appendix). Additionally, we evaluated the effect of TXA on tissue repair in the burn wound conversion zones in the severe burn model and found that TXA accelerated wound healing. Finally, we evaluated capillary leak, immune cell infiltration in the lungs as well as systemic cytokine and DAMP expression and found that all were reduced with TXA treatment (see appendix). The third year will focus on mitochondrial effects of TXA in a 60 percent TBSA burn model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1190511
Entities
People
- Damien Carter