Integrative Molecular Profiling of Whole Urine in African American Men with Aggressive Prostate Cancer
Abstract
African-American men have a high incidence of prostate cancer and experience higher mortality rates relative to other racial and ethnic populations. Early detection of aggressive disease is critical to reducing death and morbidity related to prostate cancer and, as such, is a major focus for multi-disciplinary efforts to reduce racial and ethnic health disparities. Recently, our group has developed and validated a new and innovative next-generation sequencing approach that is able to detect prostate cancer-associated germline variants, somatic alterations, and RNA biomarkers in urine, and we have demonstrated that this next generation sequencing method is significantly better at identifying men with aggressive prostate cancer than serum PSA or other urine-based molecular tests. Thus, the goal of this proposed research is to determine whether a novel integrative NGS approach to urine-based prostate cancer testing can augment early detection of African-American men with aggressive disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1190512
Entities
People
- Aaron M. Udager
Organizations
- Board of Regents of the University of Michigan