Treatment and Response Targets for Helicobacter-Associated Gastric Cancer
Abstract
The project deals with identifying treatment and response targets for Helicobacter-associated gastric cancer. The purpose is to discover novel druggable targets by testing efficacy of approved compounds. An additional purpose is to identify immune related genes as predictors of treatment response. To accomplish the goals of our project we are using fresh gastric tumor tissue samples harvested from patients undergoing gastrectomy to generate patient derived xenograft (PDX) and patient-derived orthotopic xenograft (PDOX) models. In addition, the work makes use of gastric cancer patient samples stored at our UCSDs Moores Cancer Center Biorepository core. We have successfully established a gastric cancer PDX model and show that tumor gastric tissues in the PDX model express the same genes as in the original tumor. In the first year we reported on expression of cancer markers such as the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) and the tumor-associated glycoprotein 72(TAG-72) in patient gastric tumors. These cancer markers were undetectable in normal gastric tissue. In the second year the significant finding was data showing a correlation between the expression level of a chemokine, C-X-Cmotif chemokine 5 (CXCL5) and the extent of malignancy. Figure 1 (below) shows CXCL5 expression levels in gastric cancer tumors. An accompanying summary of all patients and their gastric tumor characteristics are provided in Table 1 of an appended publication to this report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1190567
Entities
People
- Marygorret Obonyo
Organizations
- University of California, San Diego