Mechanisms of Adstiladrin Sensitivity and Resistance in Bladder Cancer

Abstract

Our hypothesis is that Adstiladrin works by novel mechanisms of action that involve both the innate and adaptive arms of the immune system, and that acquired resistance involves metabolic plasticity resulting in downregulation of fatty acid biosynthesis. Our objective is to use genomic and metabolomic approaches to identify these mechanisms in order to develop biomarkers for patient selection and novel targets for future combination therapies. Our Specific Aims are: (1) Perform genomic and metabolomic analyses on tumors and urine from the Phase 3 clinical trial; (2) Comprehensively characterize the effects of Ad-IFN on the tumor immune microenvironment; and (3) Define the role of fatty acid metabolism in Ad-IFN-induced cell death.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1190570

Entities

People

  • David Mcconkey

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Factors
  • Biological Markers
  • Biomedical Research
  • Bladder Cancer
  • Cancer
  • Cell Physiological Processes
  • Clinical Trials
  • Dna Sequence Analysis
  • Fatty Acids
  • Gene Expression
  • Gene Therapy
  • Immunotherapy
  • Maryland
  • Medical Personnel
  • Neoplasms
  • Nucleic Acids
  • Patent Applications
  • Resistance
  • Students
  • Therapy
  • Universities

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).