Reduction of Lethal Prostate Cancer Disparities in Underserved Hispanic/Latino Populations
Abstract
The proposed project will advance research into the biology of lethal prostate cancer (PCa) and reduce the burden of lethal PCa health disparities in Puerto Rican Hispanic/Latino men (PR H/L) through the following aims: Aim 1: Identify the genomic alterations and mutation signatures that characterize lethal PCa in PR Hispanic/Latino (PR H/L) men. Aim 2: Studying the lethal PCa phenotype in terms of overall DNA repair capacity (DRC) levels using lymphocytes as surrogate markers to develop a potential biomarker for identifying men at high-risk. Aim 3: To increase PCa awareness and screening in PR communities with high African ancestry and high PCa mortality rates. During this funding period, the molecular analysis for 14 prostate tumors from PR H/L men was completed: WES and RNA sequencing data are available for 11 and 14 tumors, respectively. For Aim 2, 55 samples were analyzed for DRC values including cases and controls. Significant differences were observed when comparing cases and controls (p<0.001). When stratifying by disease aggressiveness, significant differences were observed when comparing controls with aggressive or indolent groups (p<0.0001). Several oral presentations and posters regarding the data from this aim were presented at local meetings. A manuscript was published in a peer-review journal. For Aim 3, all six focus groups proposed were performed with a response rate of 105 percent. Key topics were identified from the focus group discussions including: access as a barrier to healthcare services (i.e. transportation limitation, limited number of specialists in the island, appointments are not available until various months, etc.).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1190580
Entities
People
- Carmen Ortiz
- Gilberto Ruiz Deya
- Jaime L. Matta
- Julie Dutil
- Julio Jimenez
- Melissa Marzan
Organizations
- Ponce School of Medicine