PI3K Signaling in Tumor Cells and Stroma Regulates Breast Cancer Metastasis
Abstract
Breast cancer is a major public health problem in the United States, with estimates that 40,000 women die from this disease each year. Tumor metastasis is the major cause of mortality in human breast cancer, and effective treatment of metastatic disease will require a better understanding of the signaling mechanisms that drive breast cancer cell invasion (the ability of tumor cells to move away from the primary tumor and into surrounding tissue). Our data suggests that a specific type of phosphoinositide 3-kinase, called PI3Kbeta, is strongly implicated in breast cancer metastasis. This proposal examines how PI3Kbeta regulates both tumor cells and the stromal cells that modulate tumor cell behavior, leading to increased metastasis. In particular, we have shown that hyperactivation of the PI3K pathway may supplant the role of PI3Kbeta in tumor cells. In addition, we have identified novel roles for PI3Kbeta in macrophages and platelets during the induction of tumor cell matrix degradation and invasion. Our study could establish PI3Kbeta as an important new drug target for the treatment of metastatic disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1190633
Entities
People
- Jonathan M Backer
Organizations
- Albert Einstein College of Medicine