MTDH/SND1 Protein Complex in ERG-Mediated Transformation and Therapeutic Resistance

Abstract

I found the first time that ERG could interact with SND1/MTDH protein complex in prostate cancer cell. Here I used coimmunoprecipitation and proximity ligation assays to demonstrate that ERG interacts with SND1/MTDH complex in prostate cancer cells. I also identified the protein domains in both ERG and SND1 responsible for binding between ERG andSND1/MTDH complex. Overexpression of ERG promotes transformation of RWPE-1 immortalized human prostatic epithelial cells. I found that SND1 is necessary for ERG-mediated transformation of RWPE-1 cells.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2022
Accession Number
AD1190653

Entities

People

  • Sheng-you Liao

Organizations

  • Fred Hutchinson Cancer Center

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chromosome Structures
  • Data Analysis
  • Data Science
  • Drug Resistance
  • Epithelial Cells
  • Gene Expression
  • Genes
  • Genetics
  • Inhibition
  • Knocking
  • Neoplasms
  • Prostate Cancer
  • Prostate Gland
  • Proteins
  • Resistance
  • Targets
  • Tissues

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics
  • Vision Science/Vision Psychology/Cognitive Neuroscience.