Circulating Exosomal Protein Expression for Early Prediction of Platinum Resistance in High-Grade Serous Ovarian Cancer
Abstract
High-grade serous ovarian carcinoma (HGSOC), the most common epithelial ovarian cancer, is associated with a particularly poor prognosis as most patients are diagnosed at an advanced stage owing to a lack of early detection as well as due to the eventual development of platinum-resistant. Exosomes are an attractive source of biomarkers as they carry cargo (proteins, microRNAs, and lipids) from their cells of origin, are highly stable, and can be obtained from any biological fluid using non-invasive methods. We have identification differentially expressed and unique exosomal proteins (TMEM205, CD1B, ENPL, SA-A2, EP-CR and FAS) in platinum-resistant HGSOC, however it has not yet been proven or validated as a clinical tool. Thus, there is a critical need to establish novel methods for exosomal isolation and to validate their use in detecting potential biomarkers in HGSOC. This will pave the way for exploring the clinical implications that serum exosomal proteins could have as platinum-resistance markers, prognostic indicators and therapeutic targets.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1190654
Entities
People
- Karuppaiyah Selvendiran
Organizations
- Ohio State University