Developmental Acoustic Exposure as a Novel Approach to Treat Fragile X Syndrome

Abstract

The proposed studies will test the hypothesis that a combination of sound exposure and minocycline treatment during early development will have long-lasting beneficial effects on symptoms of sensory hypersensitivity in a pre-clinical mouse model of Fragile X Syndrome (FXS), a leading known genetic cause of autism. These studies will identify for the first time the long-term efficacy of treatment during specific developmental windows in FXS. These data will have broad implications in the design of clinical trials for neurodevelopmental disorders by specifying optimal developmental treatment windows.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1190689

Entities

People

  • Devin K. Binder
  • Iryna M Ethell
  • Khaleel A. Razak

Organizations

  • University of California Regents

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biology
  • Biomedical Research
  • California
  • Cells
  • Clinical Trials
  • Department Of Defense
  • Diseases
  • Fragile-X Syndrome
  • Frequency
  • Frequency Bands
  • Genetics
  • Health Services
  • Hypersensitivity
  • Inhibition
  • Medical Personnel
  • Neurodevelopmental Disorders
  • Neurons
  • Professional Development
  • Repetition Rate
  • Students
  • Training

Readers

  • Marine Ecological Systems Migration
  • Molecular and Cellular Biology
  • Neuroscience

Technology Areas

  • Biotechnology