Investigating the Role of Creatine in Oligodendrocyte Regeneration During CNS Remyelination
Abstract
The goal of this study is to test the hypothesis that rOL protection through creatine improves CNS remyelination. To this end, we will determine i) if creatine synthesis in rOLs is required for rOL survival and remyelination, ii) if diminished creatine levels and rOL integrity contribute to remyelination impairment associated with aging, and iii) if the systemic administration of creatine and cyclocreatine (a blood brain barrier permeable creatine analog) can improve CNS remyelination. We will also determine iv) what transcripts and pathways in rOLs are affected with creatine deficiency.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190692
Entities
People
- Jeffrey K Huang
Organizations
- Georgetown University