Enhanced Melanoma Vaccine Against Neoantigens and Shared Antigens by CD40 Activation and TLR Agonists

Abstract

This project will test the hypotheses that vaccination with CD40 Ab/TLR3 agonist is safe and induces strong and durable T cell responses to the peptides in the vaccine, and that a mutated neoantigen peptide (BRAF585-614V600E) is immunogenic. There have been no findings during this reporting period as the study is not yet open at our site.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1190693

Entities

People

  • Brian Gastman

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Antigens
  • Biomedical Research
  • Cell Line
  • Cells
  • Clinical Trials
  • Contracts
  • Gene Expression
  • Governments
  • High Resolution
  • Humanities
  • Institutional Review Board
  • Local Governments
  • Lymphocytes
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Students
  • Theses
  • Training
  • Vaccination

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech