Preventing Blood Cancers and Other Malignancies in Military Personnel at Risk Due to Occupational Radiation Exposure
Abstract
We are pursuing a project to examine the amino sugar N-acetylglucosamine, via its ability to increase protein O-GlcNAcylation,as a means to promote DNA double strand break repair and thereby prevent and mitigate the toxicity of radiation in the bone marrow and other rapidly proliferative tissues, toward reducing both the acute and delayed effects of radiation, including malignancy. During the second year of research, in vitro research has progressed on a reasonable pace, though in vivo studies continue to lag. Our work to date has set the stage for a productive third year of research.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1190713
Entities
People
- Stephen J. Kron
Organizations
- University of Chicago