Optimizing Skin-Implant Interface of Osseointegrated Device
Abstract
The proposed scope work addresses bio-engineering strategies to enhance healing and functionality of osseointegrated devices for the person with an upper extremity amputation. Recognizing the role of the septal compartments at the hard tissue-soft tissue interface at the tips of appendages, the investigators are investigating methodologies to create a more durable interface. The approach is to apply a scaffold to mimic septal compartments, select and propagate stem cells with enhanced adhesive properties to promote healing and osseointegration and to prevent infection with antimicrobial coated metal device material. We have isolated, characterized and selected highly adhesive stem cells (MSCs) with plasticity for multilineage differentiation that have good scaffold ingrowth, intending them to be a population of cells that can be seeded into the scaffold and transplanted to the interface of the metal device. Animal studies are being designed and the IACUC protocol developed to measure outcome to test depth of tissue growth, preventing or limiting infection, metal-skin interface strength, and histopathology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190751
Entities
People
- Jonathan Forsberg
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine