Defining the Role for Descending Pain Modulation and Reward-Aversion Processes Towards the Development of Chronic Pain in Endometriosis
Abstract
Endometriosis, a condition in which uterine tissue grows outside the uterus, is a debilitating disease, affecting millions of women, is the leading cause of chronic pelvic pain (CPP), and is often unresponsive to existing treatments. Unfortunately, women's reproductive health has lacked investigation in biomedical research; however, given that approximately 1 in 10 women worldwide have endometriosis this research is warranted. Further research on the biopsychosocial mechanisms contributing to endometriosis-associated pain is necessary to better inform treatment and prevention and is the goal of the current proposal. The research team has made significant progress in recruiting research participants, data collection, and data analysis. The recruitment goals have been delayed due to COVID-19; however, recruitment over the last reporting period has greatly improved and is expected to continue to improve. Specifically, we believe our pre-surgical cohort will increase during this next recruitment period as surgeries may not be canceled as often due to COVID-19. We currently have recruited and tested 107 participants, with 22 participants on the schedule. Many others have expressed interest and are currently undergoing eligibility screening. These participants are in the process of being scheduled by the projects Research Assistant. The research team has also submitted several poster abstracts related to the project and has manuscripts in preparation (one review and multiple data-driven manuscripts) during this reporting period. The research team has also attended various webinars and training related to the project. On August 5, 2022, a one-year no cost extension was approved. We are confident, given current recruitment and enrollment that with the extension, the research team will complete data collection, analyses, and manuscript preparation and submission. The Continuing Review at Boston Children's Hospital was approved on Sept 12, 2022.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2022
- Accession Number
- AD1190765
Entities
People
- Christine B Sieberg
- Scott Holmes
Organizations
- University of Michigan