Acute to Chronic Pain Signatures in Traumatic Injury
Abstract
Persistent and chronic pain are significant contributors to diminished quality of life following acute musculoskeletal injury. The goal of this project is to identify critical biomarkers to predict susceptibility/resilience to the development of chronic pain after a traumatic injury. Here, we are using a population of patients with blunt chest trauma with multiple (>2) closed rib fractures, as our published prospective data indicate the chronification of pain after multiple rib fractures observed in our institution ranges from 40 to 50%. Biomarkers assessed include 1) prognostic clinical factors that predict a predisposition for susceptibility and/or resilience to pain chronification; 2) functional brain imaging biomarkers associated with the development of chronic pain; and 3) nociceptive genetic patterns at the time of injury that are predictive of pain chronification.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190772
Entities
People
- Jennifer E Nyland
Organizations
- Pennsylvania State University