The Role of Mitochondria in ADT-Induced Sarcopenia in Prostate Cancer Patients

Abstract

Prostate cancer (PCa) is the most common cancer among men. Androgen deprivation therapy (ADT)is the standard treatment for advanced and metastatic PCa and nearly 400,000 men remain on androgen deprivation therapy (ADT) for advanced PCa in the U.S. Unfortunately, ADT also induces a decrease in muscle mass and function, known as sarcopenia, a condition that leads to decreased endurance, increased fatigue, falls, poor health-related quality of life (HRQOL) and increased mortality. The mechanisms underlying the development of ADT-induced sarcopenia are incompletely understood and remain a significant barrier to the development of therapies for this condition. Mitochondria play an essential role in generating the adenosine triphosphate (ATP) needed for muscle contraction and abnormalities in mitochondria function have been reported in animal models of sarcopenia. The extent to which mitochondrial dysfunction mediates ADT-induced sarcopenia and muscle dysfunction is not known.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1190790

Entities

People

  • José M. Garcia

Organizations

  • Seattle Institute for Biomedical and Clinical Research

Tags

DTIC Thesaurus Topics

  • Androgens
  • Biomedical Research
  • Body Composition
  • Cancer
  • Cellular Structures
  • Clinical Trials
  • Department Of Defense
  • Department Of Veterans Affairs
  • Diseases
  • Health
  • Health Care
  • Health Services
  • Hormones
  • Medical Personnel
  • Metabolomics
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Quality Of Life
  • Skeletal Muscle
  • Standards
  • Training
  • United States

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