The Impact of Gulf War Inhalant Pollutant and Chemical Exposures on the Upper Sinonasal Airway

Abstract

Despite upper respiratory disease (i.e. chronic rhinosinusitis) debilitating a significant proportion of Gulf War (GW) Veterans, data regarding the impact of GW exposures on the sinonasal airway remain limited. The proposed research aims to investigate the effects of GW chemical and pollutant exposure on tissues of the sinonasal tract, which to date has not been fully characterized. We hypothesize that GW toxicant and particulate matter exposures from pesticides and oil well fire effluents contribute to the underlying pathophysiology of Gulf War Illness associated sinonasal disease. This translational study utilizes 3 parallel but complementary systems to elucidate the molecular, cellular, and microbiome changes in sinonasal epithelia that arise from GW airborne chemical and pollutant exposures.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1190803

Entities

People

  • Jivianne T. Lee
  • Saroj Basak

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Cell Line
  • Cells
  • Culture Techniques
  • Cultured Cells
  • Cytokines
  • Delivery Of Health Care
  • Department Of Defense
  • Dermatologic Agents
  • Diseases
  • Drug Abuse
  • Electronic Mail
  • Epithelial Cells
  • Epithelium
  • Governments
  • Local Governments
  • Medical Personnel
  • Oxidative Stress
  • Particulate Matter
  • Persian Gulf Syndrome
  • Professional Development

Fields of Study

  • Environmental science

Readers

  • Environmental Engineering.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.