Sequential versus Combined Medical Therapies as a Novel Heterotopic Ossification Prevention Strategy
Abstract
The long-term treatment of military warfighters who sustain severe battlefield blast-related extremity injuries and/or multiple limb amputationsis one of the major challenges for military healthcare providers. A common complication facing modern combat casualties is the extraskeletal development of bone within damaged/healing tissue resulting in soft tissue heterotopic ossification (HO). HO is more prevalent inmilitary trauma, occurring in approximately 65-67% of amputations and nearly 62% of limb sparing procedures. Importantly, cliniciansdescribe HO as the single most important barrier to meaningful functional mobility, independence, and return to military service. In theproposed research, we will use our physiologic model of blast and extremity trauma-induced heterotopic ossification (HO) to test andinvestigate two drugs (Palovarotene and Rapamycin) which are FDA approved and are currently used clinically for various indications, sothat our goal of reaching clinical trials in human patients within five years can become realistic. Our physiologic model of blast-related HOextremity injury incorporates many of the same critical injury patterns detected in combat service members causalities with acute extremityinjuries/amputation, including blast overpressure exposure, a comminuted femur fracture, and crush injury to the surroundingmusculoskeletal tissue.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2022
- Accession Number
- AD1190804
Entities
People
- Carolyn Gosztyla
- Stephen Kaba
Organizations
- Naval Medical Research Center