Nonopioid Chronic Pain Treatment by Erasing Spinal Pain Memory
Abstract
This project is to rigorously evaluate if activating spinal GPR37 (G protein-coupled receptor 37) has a potential of treating and preventing pain chronification by erasing 'spinal pain memory' without posing a risk of abuse. As the first step, we determined if the putative GPR37 agonists TX14A and protectin D1 (PD1) produce any adverse effects on normal motor and sensory functions when given intrathecally. We found that TX14A at doses 10-50 ug and PD1 1at 50-100 ng had no immediate (1 hour post intrathecal injection) or long-lasting (24 hour) effect on the grip strength and rotarod performance. In addition, at these doses, the two agonists did not affect normal mechanical and heat sensitivity longitudinally measured up to 24 hours post intrathecal injection. In the intraplantar capsaicin injection model, TX14A facilitated the resolution of mechanical pain hypersensitivity produced by the acute chemical injury. These results suggest that activating spinal GPR37 erases an acute injury-induced spinal pain memory without affecting normal motor and sensory functions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190857
Entities
People
- Jun-Ho La
Organizations
- University of Texas Medical Branch