Targeting the Endotheliopathy of Trauma in Hemorrhagic Shock and Traumatic Brain Injury with Freeze-Dried Platelets

Abstract

The goal of this project is to test the therapeutic potential of freeze dried platelets-FDPlts (Thrombosomes)- in disease conditions characterized by 1) inflammation, 2) vascular instability and 3) coagulation disturbances, which are all components of the endotheliopathy of trauma (EOT) (refs). Aside from their hemostatic properties, this proposal aims to also determine the mechanisms of action of the freeze dried platelets (FDPlts (Thrombosomes)) on the EOT in traumatic brain injury (TBI) and shock induced acute lung injury (ALI); all conditions with few if any effective treatment options.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2022
Accession Number
AD1190885

Entities

People

  • Alpa Mahuvakar
  • Shibani Pati

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Arteries
  • Blood
  • Blood Vessels
  • Blood-Brain Barrier
  • Brain Injuries
  • Cell Membrane Structures
  • Cells
  • Cells (Biology)
  • Confocal Microscopy
  • Data Analysis
  • Department Of Defense
  • Endothelial Cells
  • Hemorrhagic Shock
  • Intercellular Junctions
  • Medical Personnel
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Trauma Surgery or Emergency Medicine.