High-Definition Transcranial Direct Current Stimulation in Episode Memory in Individuals with Amnestic Mild Cognitive Impairment and History of TBI
Abstract
Traumatic brain injury (TBI) is a risk factor for earlier development of Alzheimer dementia (AD), and amnestic mild cognitive impairment (aMCI) is often a prodromal stage for AD, representing the earliest clinical threshold where episodic memory deficits manifest. The pre-supplemental motor area (preSMA) and dorsal anterior cingulate cortex (dACC) have been shown to play a role in episodic memory retrieval. Prior studies from our group have demonstrated that the memory circuity appears amenable to HD-tDCS modulation of the preSMA/dACC, with significant improvement in episodic memory seen in patients with a history of TBI. However, there is an absence of studies examining the efficacy of HD-tDCS to improve episodic memory in individuals with aMCI and a history of TBI. Research Strategy: To address this, the proposed project would be the first to assess whether HD-tDCS can improve episodic memory in aMCI individuals with a history of TBI. This will be a randomized, blinded study with two arms of intervention (active HD-tDCS stimulation or sham condition). A total of 24former military and non-military participants with aMCI and a history of TBI will be randomized into the two intervention conditions based on a2:1 ratio (Active n=16 versus Sham n=8). Participants will receive 10 sessions of either active HD-tDCS stimulation to the preSMA/dACC or sham across 2 weeks. A neuropsychological test battery consisting of episodic memory measures will be completed at baseline, immediately following session 10, and at a 3-month follow-up.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190919
Entities
People
- Christian LoBue
Organizations
- University of Texas at Dallas