UTE MRI: A Novel Biomarker for Remyelination in Multiple Sclerosis Patients
Abstract
Hypothesis UTE MRI can be applied to MS patients undergoing myelin repair therapy and provide specific measurements of myelin non-invasively across the entire brain. Objectives Apply UTE MRI to MS patients undergoing remyelinating therapy; analyze the imaging results in comparison to electrophysiology, in known lesions, and across the white matter Rationale The scientific premise of this proposal is that the capability of UTE MRI to directly measure signals from the myelin phospholipid membranes has the potential to transform non-invasive assessment of myelin by providing a more specific measurement of myelin density and structure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1190973
Entities
People
- Peder Larson
Organizations
- University of California Regents