Neurophysiologic Mechanisms of Freezing of Gait: Disentangling Phenotypic Heterogeneity with Mobile EEG and Wearable Kinematic Sensors
Abstract
Freezing of gait (FOG) is a disabling complication of Parkinsons disease (PD) characterized by episodes of difficulty continuing or initiating walking. The goal of this research is to identify neural correlates of freezing susceptibility, onset and recovery, and how these mechanisms relate heterogeneity in FOG phenotypes using state of the art mobile brain body imaging (MOBI) techniques. 60 patients with PD perform a walking task employing multiple trigger types (dual task, doorway, initiation, turning, cluttered environment) during high density electroencephalography (EEG) and movement kinematic recordings under three conditions: no cues, visual cues and auditory cues. The project is in the data collection phase, and we have enrolled and completed data collection in 18 patients with Parkinson disease. Interim analyses of individual subject data demonstrate expected gait-related neural activity modulation and modulation of gait kinematics by sensory cues, indicating adequate data quality for planned group analyses relating gait kinematics and EEG data across the cohort.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1191029
Entities
People
- Kathryn Cross
Organizations
- University of California, Los Angeles