Oxandrolone Supplementation in Trauma: The Post-Injury Trial
Abstract
The POST-Injury Trial addresses the rehabilitation techniques and outcomes after high-energy, lower extremity fractures. These injuries require extensive rehabilitation and often multiple surgeries and typically result in permanent limitations of physical function. Furthermore, unlike low-energy fractures, these patients incur multiple insults to their soft tissues from both the initial injury and as a result of treatment. This is further compounded by any post-operative immobilization and associated volumetric muscle loss. The process of recovery is long, and the result is often an incomplete functional recovery with residual disability. Within the United States military, musculoskeletal injuries account for 53-76% of medically nondeployable Service Members, of which 65%-92% are due to volumetric muscle loss after high-energy trauma and fracture. There have been a lack of efficacious interventions available to offset the metabolic and mechanical sequalae associated with high-energy trauma and prolonged immobilization. Oxandrolone has been successfully utilized to reduce muscle loss, accelerate muscular recovery, and improve physical function in large surface area burns in similar populations and may be translatable to high-energy, lower-extremity fracture patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1191046
Entities
People
- Scott M. Tintle
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine