Roles of Lymphatic Vessels in Cardiac Tissue Regeneration
Abstract
Heart failure is the leading cause of death in the US and globally. There is a pressing need for novel therapeutic interventions to prevent heart failure in patients with coronary heart diseases. Tissue regeneration holds great promise of treating organ injures and chronic diseases, including coronary heart disease. We proposed to investigate the roles of cardiac lymphatic vessels in revascularization and immune cell modulation, two processes important for heart regeneration. Our preliminary data suggest that cardiac lymphatic vessels can carry blood and perfuse myocardium of zebrafish, an animal with remarkable capacity of heart regeneration. These cardiac lymphatic vessels form in close association with coronary arteries, and this morphology is conserved with human hearts. We also found that hearts with impaired cardiac lymphatic vessels fail to regenerate. Furthermore, we discovered sex and injury model dependent mechanisms of cardiac lymphatic vessel formation and its role in heart repair and regeneration. These molecular mechanisms underlying cardiac lymphatic vessel formation after heart injury might lead to development of novel therapeutic designs for myocardial revascularization and regeneration.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2022
- Accession Number
- AD1191055
Entities
People
- Ching-ling Lien
Organizations
- Children's Hospital Los Angeles