Hereditary X-Linked Tumor Suppressor Escapes Immune Control in Prostate Cancer
Abstract
In our recent work, we isolated an X-linked signal predisposing men to prostate cancers in2,700 families ascertained for hereditary ovarian cancers. We sequenced and found acandidate variant on Xq27.2 in MAGEC3 suggesting that HPCX may connect prostate and ovariancancers. Our preliminary experiments show that, in a tetracycline inducible system,heterologous MAGEC3 may be associated with an anti-proliferative phenotype consistent with atumor suppressor. We hypothesize that MAGEC3 is a heritable tumor suppressor that issilenced in prostate cancers leading to disease progression. Aim 1 is to confirm theconnection between prostate and ovary families by segregation and germline X chromosomesequencing in family studies and in men with a relevant family history.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2022
- Accession Number
- AD1191065
Entities
People
- Kent Nastiuk
Organizations
- Health Research, Incorporated