Cell Communication in Antiestrogen Resistance

Abstract

More women die from the estrogen receptor positive (ER+) breast cancer subtype than from any other. The proportion of early ER+ recurrences (=5 years since diagnosis) approaches that for all triple-negative breast cancers alone. Late recurrences (>5 years after diagnosis), the result of dormancy, are most common in ER+ disease and can arise decades after the initial diagnosis. Since recurrent breast cancers have escaped the effects of endocrine therapies, and are lethal, we will study endocrine resistance(Tamoxifen; Fulvestrant). Our primary objective is to identify what drives breast cancer growth and determine how to stop it. We will learn about why some breast cancers are aggressive and others are indolent, and why/how some breast cancers lay dormant for years and then re-emerge.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1191069

Entities

People

  • Robert Clarke
  • Yue Wang

Organizations

  • University of Minnesota

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  • Alzheimer Disease
  • Biomedical Research
  • Breast Cancer
  • Cancer
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  • Breast cancer cell signaling and growth regulation.
  • Data Mining and Knowledge Discovery.
  • Oncology