Long-Term Vascular-Related Cognitive Decline after Traumatic Brain Injury
Abstract
The overall objective of this project is to use rigorously developed sophisticated biostatistical and epidemiological methods that account for study attrition to model cognitive trajectories assessed at multiple time-points over 5 years of follow-up and to determine if individuals with TBI and vascular risk factors have less cognitive recovery in the first year post-TBI and have greater cognitive decline over years1-5 post-TBI compared to individuals with comparable TBI without vascular risk factors and to controls. The overarching hypothesis of this project is that individuals with TBI and vascular risk factors will have less cognitive recovery over the first year post-TBI and greater cognitive decline over years 1-5 post-TBI than individuals with comparable TBI without vascular risk factors and controls. Further, we hypothesize that individuals with TBI and greater severity of vascular risk factors will have less cognitive recovery over the first year post-TBI and greater cognitive decline over years 1-5 post-TBI compared to individuals with comparable TBI and lower severity of vascular risk factors or no vascular risk factors and controls. This project has the potential to generate the following innovative deliverables: 1.) identifying vascular risk factor reduction as a high-priority target for dementia prevention strategies and clinical trials in TBI populations, and 2.) developing biostatistical and epidemiological methods to model cognitive trajectories post-TBI that account for study attrition that can be shared with other investigators and translated both within and across studies with the goal of collaboratively advancing research on post-TBI cognitive decline and dementia.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1191101
Entities
People
- Andrea Schneider
Organizations
- University of Pennsylvania