Cold Stored Platelet Early Intervention (CriSP) Trial
Abstract
CriSP-HS is a proposed 3-year (2 years of enrollment), open label, multi-center, randomized trial designed to determine the feasibility, efficacy and safety of urgent release cold store platelets in hemorrhagic shock patients. Specific aim one is to determine the feasibility, most appropriate study population and primary outcome that will lead to a large multicenter clinical trial designed to evaluate the effectiveness of cold stored platelet early intervention in patients with injury and hemorrhagic shock. Specific aim two is to determine whether early cold stored platelet infusion compared to standard care results in improved clinical outcomes and hemostatic function in injured patients with hemorrhagic shock inpatients. Specific aim three is to determine if early cold stored platelet hemostatic function is similar at 1 through 7 days as compared to 8 through 14 days in patients with hemorrhagic shock in patients. CriSP-TBI is a proposed 3-year open label, single center, randomized trial designed to determine the feasibility, efficacy and safety of urgent release cold stored platelets in blunt injured patients with traumatic brain injury requiring platelet transfusion. Specific aim one is to determine the feasibility, most appropriate study population and primary outcome that will lead to a large multicenter clinical trial designed to evaluate the effectiveness of cold stored platelet early intervention in patients with TBI requiring platelet transfusion. Specific aim two is to determine whether early cold stored platelet transfusion compared to standard platelet transfusion results in improved hemostatic function and clinical outcomes in patients with traumatic brain injury requiring platelet transfusion. Specific aim three is to determine if early cold stored platelet hemostatic function is similar at 1 through 7 days as compared to 8 through 14 days in patients with TBI on antiplatelet therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1191110
Entities
People
- Ashley Harner
- Jason Lee Sperry
- Laurie Ney Silfies
- Meghan Buck
- Natalie Rogers
Organizations
- University of Pittsburgh