A Nanotechnology Solution for Early Detection of Micrometastatic Prostate Cancer after Radical Prostatectomy

Abstract

The overall objective of this research proposal is to conduct the initial development of a rapid circulating tumor cell-based blood test that can identify men with micrometastatic disease in order to facilitate patient selection for salvage radiotherapy. Aim 1 of this study was do perform a technical validation study and Aim 2 to embark upon testing of banked clinical specimens then to test the new assay in the setting of the NRG-GU-006 clinical trial (salvage radiotherapy +/- apalutamide). In the first year of work we have begun a series of key technical validation studies while completing the sample collection from the now fully accrued NRG-GU-006 trial. Due to COVID-19 there were delays in progress but due to rapid clinical accrual and regearing of our studies, this effort is still on time.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1191117

Entities

People

  • Edwin M Posadas

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Calibration
  • Cancer
  • Cell Line
  • Clinical Trials
  • Data Analysis
  • Detection
  • Diseases
  • Gene Expression
  • Health Services
  • Medical Personnel
  • Nanotechnology
  • Neoplasms
  • Oncology
  • Prostate
  • Prostate Cancer
  • Therapy
  • Validation

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology