Genetics of Frontotemporal Degeneration in Diverse Populations

Abstract

Genomic analyses in diverse populations of frontotemporal dementia patients are currently lacking. Here we present the first report on creation of a (Caribbean) Hispanic cohort through enrollment in the greater South Florida area and Puerto Rico as well as well the first genomic analyses using genotyping and whole genome sequencing approaches. Enrollment was delayed due to COVID-19 hesitancy but plans are in place to improve in the next reporting period. Further efforts to increase outreach are being developed. Preliminary analyses indicate good representation of diverse genetic ancestries in the dataset and no known FTD mutations in genes originally identified in European FTD patients were identified so far. Whole genome sequencing and genotyping on the full cohort is currently ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2022
Accession Number
AD1191150

Entities

People

  • Karen Nuytemans

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alzheimer Disease
  • Biomedical Research
  • Covid-19
  • Data Sets
  • Dementia
  • Department Of Defense
  • Diseases
  • Genetics
  • Genomics
  • Health
  • Health Services
  • Medical Genetics
  • Medical Personnel
  • Memory Disorders
  • Neurology
  • Puerto Rico
  • Universities
  • Whole Genome Sequencing

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Molecular Genetics
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Biotechnology