Generation of a Mouse Model to Investigate IL-6 Trans-Signaling in ALS

Abstract

We hypothesize that IL6 transsignaling plays a role in the progression of ALS by affecting the rate of NMJ denervation, glial cell activation, and MN degeneration. Given the difficulty studying humans with ALS and collecting samples critical to studying active disease, we are proposing to utilize the SOD1G93A mouse model of ALS to study the effects of IL6 transsignaling on disease severity and progression. Successful execution of this study will define the role of IL6 as an effector of ALS severity and progression, and will provide new information on how to target and treatment ALS using therapeutics that target and block the detrimental effects of IL6 transsignaling.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1191160

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  • Carol Milligan
  • Gregory Hawkins

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  • Wake Forest University

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