Chromatin Accessibility and the Convergent Oncogenic Pathways of Angiosarcomas
Abstract
Angiosarcoma is a rare type of soft tissue sarcoma, with a prevalence of fewer than 300cases in the US annually. Our understanding of the oncogenic mechanisms of aggressive angiosarcomas is rudimentary, and our ultimate goal is to develop appropriate and effective treatment options and protocols for patients with this disease. Angiosarcoma are genomically complex; however, they share a histological morphology that consists of disorganized, malignant vessel-forming cells. Our hypothesis is that chromatin accessibility is necessary to establish the mutational landscape, which consequently activates convergent signaling pathways that contribute to angiosarcoma development. In this report period, we established chromatin accessibility and the transcriptomic landscape in TP53 mutant hemangioblast cells differentiated from human induced pluripotent stem cells. This approach allows us to develop in vitro tumor models to define molecular mechanisms that regulate convergent oncogenic pathways in angiosarcomas. We will determine if p53 deficiency in hemangioblasts contributes to angiosarcoma development. This project will impact our understanding of aggressive angiosarcomas and specifically enhance our basic knowledge of how morphologic convergence with genetic chaos arises and contributes to angiosarcoma development. This career development award also supported the PI, Dr. Kim's career goal to develop an independent research program to advance our understanding of aggressive sarcomas. Likewise, Dr. Kim was hired by University of Florida as a tenure-track faculty in this period, and he successfully continues to establish his outstanding research program.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1191170
Entities
People
- Jong H. Kim
Organizations
- University of Florida
- University of Minnesota