Single-Cell CRISPRa Screen to Identify Transcription Factors That Mediate Neuroblastoma Phenotypic Switching and Chemotherapy Drug Resistance

Abstract

Objectives: I hypothesize that there are other ADRN-and MES-specific TFs that can mediate trans differentiation and in extension chemotherapy resistance. Furthermore, I propose that the combinatorial cooperation of several TFs will be more potent than a single TF to facilitate this process. To test my hypothesis, I propose two specific aims: 1) aim 1 is to identify TFs and TF combinations that regulate NB trans-differentiation; 2) aim 2 is to identify TFs and TF combinations that contribute to chemotherapy resistance of NB.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1191200

Entities

People

  • Zhihui Liu

Organizations

  • Geneva Foundation

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cell Line
  • Cells
  • Chemotherapy
  • Department Of Defense
  • Dna Sequence Analysis
  • Drug Resistance
  • Information Operations
  • Maryland
  • Neoplasms
  • Neuroblastoma
  • Patent Applications
  • Professional Development
  • Resistance
  • Switching
  • Technology Transfer
  • Transcription Factors

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