Age-Associated Microglia/Macrophage Response Inhibits Remyelination
Abstract
The purpose of this research is to evaluate whether reactive oxygen species are an age-associated inhibitor of remyelination. We will evaluate ROS deposition during remyelination, evaluate the sources of ROS, and use ROS lowering medications to evaluate how impacts remyelination We will use animal models of remyelination, microglial fate mapping, ROS measuring techniques and single cell RNA sequencing of ROS enriched cells to evaluate the source of ROS production. We will use medications to lower ROS and evaluate how ROS impacts remyelination. Currently we have conducted microglial fate mapping and found that age is associated with a delayedaccumulation of microglia without altering monocyte-derived macrophage entry.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1191201
Entities
People
- Jason R Plemel
Organizations
- University of Alberta