Regenerative Immunotherapies

Abstract

The proposed project, Regenerative Immunotherapies, is directly responsive to FY18 PRMRP Topic Area of Tissue Regeneration. The proposal presents "original ideas that foster new directions" in the field of regenerative medicine research. The overall goal of this proposal is to leverage the immune system to promote tissue repair after injury. The immune system is one of the first responders to tissue damage and sets the stage for subsequent repair processes such as stem cell mobilization, vascularization and extracellular matrix production. The immune system has experience in tissue repair as it inevitably damages tissue during response to infection. Targeting this early mechanism in both biomaterial and wound healing responses, we can change the paradigm in regeneration research and start to increase the clinical impact in functional repair. Furthermore, this approach may also facilitate the use and function of stem cells and other currently used tissue engineering strategies.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1191285

Entities

People

  • Jennifer Elisseeff

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biomedical Research
  • Cells
  • Culture Techniques
  • Diseases
  • Engineering
  • First Responders
  • Immune System
  • Immunomodulation
  • Immunotherapy
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Regenerative Medicine
  • Standards
  • Stem Cells
  • Students
  • Therapy
  • Tissues
  • Wound Healing
  • Wounds And Injuries

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech