Mismatch Repair Loss Renders ER+(plus)/HER2- Breast Cancer Susceptible to HER2/3 Inhibition

Abstract

The objective of this proposed study is to investigate a role for HER2/3 activation in MutLdefective ER+ breast cancer progression and resistance to endocrine therapy. By targeting HER2/3 signaling and key nodes of adaptive kinome response, we aim to significantly improve patient disease-specific survival.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1191305

Entities

People

  • Meghashyam Kavuri

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Clinical Trials
  • Computational Science
  • Data Mining
  • Data Sets
  • Growth Factors
  • Information Science
  • Intellectual Property
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Proteins
  • Regression Analysis
  • Standards
  • Students
  • Therapy

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.