Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression

Abstract

The purpose of this project is to determine the roles of Piezo mechano-sensing channels in osteoarthritis (OA) and pain associated with OA using mouse genetic models. Two major aims are proposed. 1) assessment of the effect of cartilage-specific loss of Piezo1 and Piezo2 in OA progression in surgically created OA in mice, and 2) assessment of OA-associated pain in Piezo2 haplo-insufficient mice.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1191325

Entities

People

  • Tatsuya Kobayashi

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Arthritis
  • Biomedical Research
  • Bone And Bones
  • Cartilage
  • Connective Tissue Cells
  • Demographic Cohorts
  • Disease Attributes
  • Diseases
  • Electronic Mail
  • Fluid Flow
  • Gene Expression
  • Health Services
  • Inhibition
  • Management Personnel
  • Maryland
  • Medical Personnel
  • Organizational Structure
  • Pain
  • Professional Development
  • Shear Stresses
  • Stresses
  • Validation

Readers

  • Enterprise Information Systems Architecture and Joint Command Capability Interoperability Support.
  • Military History
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech