Determination of Intranasal Deposition of Particles in Anatomically Correct Physical Models of Children and Adults and Comparison with Previous Studies
Abstract
Physical models of the respiratory system provide a method for quantifying particle deposition in humans without exposing them to toxic agents. In this study, intranasal deposition of 0.58-10 micrometers particles of Arizona Test Dust was quantified in 3D printed models of 2-, 5-, and 18-year-old humans at flow rates representing sitting-awake, light-activity, light-exercise, and heavy-exercise conditions. Intranasal particle deposition was calculated as a function of impaction parameter. Results from this study were compared with previously published results in which liquid particles were used on age-matched humans and 3D models. Similar to findings from the previous studies, results from the present study showed that impaction is the predominant deposition mechanism for dry particles in intranasal airways. In addition, results for intranasal deposition in the present study showed agreement with results obtained in the previously published studies, which validates the use of these models to conduct deposition studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2023
- Accession Number
- AD1191523
Entities
People
- Beth Laube
- Jana Kesavan
- Joanna A. Canagarajah
- Keith Sedberry
- Valerie Alstadt
Organizations
- CFD Research Corporation (United States)
- Drexel University
- Oak Ridge Institute for Science and Education
- United States Army Combat Capabilities Development Command