Bridging Epigenomics and Patient Data to Detect Enhanceropathies in Cancer

Abstract

The objectives of this proposal are to integrate gene regulation data with large-scale patient genotype and Electronic Medical Record (EMR) data to identify and characterize novel, non-coding genetic markers of lymphoma and blood cancers. In the first year of this award, we have made substantial progress towards the stated goals of the project, despite the delays brought on by COVID19. Specifically, we have identified new non-coding single nucleotide polymorphisms (SNPs) tagging gene enhancers associated with risk for lymphoid cancer and have further refined our protocols for SNP prioritization. We have developed new protocols for functionally analyzing non-coding SNPs using a new massively parallel reporter assay and have submitted a manuscript currently in press.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2022
Accession Number
AD1191715

Entities

People

  • Emily C. Hodges

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Cancers
  • Blood Cells
  • Cancer
  • Cells
  • Chemistry
  • Data Analysis
  • Department Of Defense
  • Diseases
  • Epigenomics
  • Gene Expression
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Genome
  • Human Genome
  • Leukocytes
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Stem Cells
  • Students
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology and Biomarker-Based Cancer Detection.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology
  • Microelectronics