Low-Cost, High-Throughput 3D Pulmonary Imaging Using Hyperpolarized Propane Gas
Abstract
This report covers the second year of this three-year project. During the indicated period of performance, we have focused our activities on all three specific aims. With regards to Aim number 1 (to develop a clinical low-cost and high-throughput device for production and administration of HP propane contrast agent for ultimate research use in volunteers), we have continued working on testing the robustness of the portable propane hyperpolarizer device. With respect to Aim number 2 (To develop a safe method for HP propane gas administration and utilization, and test the purity and safety of the HP contrast agent produced by our device)we have employed previously developed approaches (during Y1) to continue work on testing the quality of the produced gas in the context of reaction completeness and the levels of polarization. While the progress of working on all aims of this project has been substantially impacted by the COVID-19 pandemic, this year we made some progress towards Aim number 3 (To assess the feasibility of MRI using HP propane gas for in vivo functional imaging of normal lungs and in a bleomycin-induced COPD model in sheep) - specifically, we have completed the installation of 0.35 T clinical MRI scanner, performed personnel training, and installed 129Xe torso imaging coil and performed MRI scanner upgrade with 129Xe capability at WSU. Moreover, the partnering site (SIUC) has completed installation of a portable MRI scanner and has demonstrated its utility for hyperpolarized proton MRI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1192312
Entities
People
- Eduard Y. Chekmenev
Organizations
- Wayne State University