A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

Abstract

Objective: To explore the genotypic and phenotypic characteristics of African American men that exhibit system/chronic inflammation. Impact: This study explores the relationship between systemic/chronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammation and tumor biology affects prostate cancer progression in a high-risk population, like African American men, offers the opportunity to develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1192598

Entities

People

  • Clayton Yates

Organizations

  • Tuskegee University

Tags

DTIC Thesaurus Topics

  • Africa
  • African Americans
  • Biology
  • Biomedical Research
  • Department Of Defense
  • Disease Attributes
  • Diseases
  • Gene Expression
  • Genetic Variation
  • Genetics
  • Genomics
  • Inflammation
  • Lymphocytes
  • Mutations
  • Neoplasms
  • Personalized Medicine
  • Precision
  • Professional Development
  • Prostate
  • Prostate Cancer
  • Risk Factors
  • Rna Sequence Analysis
  • Tissues

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.