Novel Combinatorial Approaches to Repair Visual System After Optic Nerve Damage

Abstract

Background: The neurons in the eye called retinal ganglion cells (RGCs) send visual information through nerve fibers that travel into the optic nerve to reach the brain. Damage to the optic nerve resulting from traumatic brain injury (TBI) and traumatic optic neuropathy (TON) can result in the death of these neurons,and subsequent visual impairment. There is no treatment available to restore vision once the damage is done.We have previously discovered specific genes that induce robust optic nerve regeneration in mice.Additionally, we have demonstrated that genetic modification of cell death-related genes render RGCs highly resistant to injury.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1192618

Entities

People

  • Kevin K. Park

Organizations

  • University of Miami

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Central Nervous System
  • Craniocerebral Trauma
  • Data Displays
  • Eye Diseases
  • Gene Therapy
  • Genetic Engineering
  • Hypothermia
  • Medical Personnel
  • Nerve Fibers
  • Nerves
  • Nervous System
  • Neuropathy
  • Optic Nerve
  • Students
  • Survival
  • Therapy

Readers

  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.

Technology Areas

  • Biotechnology