Targeted Nutritional Approach to Improve Muscle Function and Physical Activity by Restoring Metabolic Deregulations During Recovery from Sepsis
Abstract
Purpose: The major goal is to test the hypothesis that a unique formulation based on essential amino acids (EAA) will improve physical activity, and involuntary isometric skeletal muscle strength faster during the recovery of a sepsis event. Scope: The proposed study in a catheterized pig model recovering from sepsis is innovative because, a) the targeted nutritional supplementation is a novel approach to attenuate tissue breakdown in sepsis and improves functional outcome and restores muscle mass, and it provides insights into sepsis-induced severe tissue breakdown and physical outcome. The use of innovative, stable tracer methodology to measure metabolic fluxes within and across muscle, enables quantification of all metabolic endpoints. The results of the study will have a positive impact by providing the basis to develop novel cost-effective nutritional approaches for patients recovering from sepsis to improve recovery and rehabilitation. It has a strong justification because of its rapid translation into clinical application. Year 2 Achievement: We performed studies in 32 animals with some delay due to Covid-19, change of animal vendor, and animal supply. We implemented/validated the analysis of the animal activity and implemented the analysis of the muscle strength responses. No changes needed to current approach.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1193023
Entities
People
- Gabriella Ten Have
- Nicolaas Deutz
Organizations
- Texas A&M University