Prostate-Specific Membrane Antigen-Dependent Health Disparities in Prostate Cancer
Abstract
According to published data, African American (AA) men AA men are 1.6 times more susceptible to developing prostatecancer, and about 2 times more likely to die from this disease than men of European (EUR) descent. In fact, even whenenvironmental factors are corrected, the disparity in mortality rate between AA and EUR men is higher for prostate cancer thanthat for any other malignancy, thus suggesting a molecular component. The Caromile lab is investigating if germline singlenucleotide polymorphisms, or SNPs, within certain components of the PSMA signaling pathway might contribute to theincreased risk of prostate cancer in AA men vs that of EUR men. Investigation into these molecular mechanisms not only hasthe potential to improve the outcomes of all men with lethal prostate cancer but also has the capability to reduce prostatecancer disparities by improving detection, morbidity, and mortality of lethal prostate cancer in AA and other at-risk populationsthrough the identification of unique, tailored treatment and prevention strategies for each patient.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1193027
Entities
People
- Leslie A Caromile
Organizations
- University of Connecticut Health Center