Pathogenic T Cells in Guillain Barre Syndrome
Abstract
The human disease, Guillain Barre Syndrome (GBS), can be modeled in NOD.AireGW/+ mice that acquire an autoimmune peripheral neuropathy (APN). We have learned that APN in these mice requires UTX expression inCD4+ T cells. The goal of this project is to understand how UTX in T cells promotes APN, focusing on UTX's effects on gene expression in CD4+ T cells and the formation of pathogenic subsets of CD4+ T cells. In year 1, we worked toward understanding the role of UTX's demethylase domain in APN. In one series of experiments, NOD.AireGW/+ mice were treated with a compound that inhibits the UTX demethylase activity. We observed that this treatment failed to prevent APN, suggesting that UTX function is demethylase-independent. We also worked toward establishing a genetic model where APN-prone mice will express a mutant form of UTX that lacks demethylase activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1193031
Entities
People
- Jason K Whitmire
- Maureen A Su
Organizations
- University of California, Los Angeles