Respiratory Mechanics in Traumatic Brain Injury (TBI) The Effect of Inhaled Nitric Oxide

Abstract

Background: The etiology of post- traumatic brain injury (TBI) hypoxemia is multifactorial including ventilation/perfusion mismatch and loss of pulmonary hypoxic vasoconstriction. Inhaled nitric oxide (iNO) has been studied as an adjunct treatment to avoid the use of high positive end-expiratory pressure (PEEP) and inspired oxygen. We hypothesized that iNO after TBI would improve systemic and cerebral oxygenation via improved matching of pulmonary perfusion and ventilation. Methods: Thirteen human patients were enrolled following isolated TBI and were randomized to receive either placebo or iNO group with measurement of pulmonary parameters, blood gas data, and intracranial variables. To complement this study, a porcine model of TBI was utilized with bilateral blood flow and oxygenation intracerebral monitoring.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2022
Accession Number
AD1193652

Entities

People

  • Adam D. Price
  • Chelsea Caskey
  • Dina Gomaa
  • Maia Smith
  • Matthew R. Baucom
  • Michael D Goodman
  • Richard D Branson
  • Richard Strilka
  • Thomas C Blakeman
  • Timothy A. Pritts

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Air Force
  • Air Force Research Laboratories
  • Airway Management
  • Blood
  • Blood Flow
  • Blood Gases
  • Blood Pressure
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Governments
  • Head Injuries
  • Human Performance
  • Lung Diseases
  • Measurement
  • Oxygenation
  • Partial Pressure
  • Respiratory Physiological Phenomena
  • Skull
  • Space Force
  • United States
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Neurotrauma and Rehabilitation Medicine.